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In the ACHIEVE-1 phase 3 trial, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with early type 2 diabetes.
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Current guidelines do not recommend GLP-1 receptor agonists during pregnancy because we dont yet have enough safety data., But this study caught my attention., Researchers analyzed 36,963 pregnancies ...
Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1 - ScienceDirect
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